Vascarta Inc.’s VAS-101 (Vasceptor), an innovative topical curcumin treatment, has just received Orphan Drug Designation from the FDA. This status could fast-track its development, offering hope for safer, more effective pain relief and disease management for sickle cell patients. Unlike traditional oral curcumin (which struggles with absorption), VAS-101 uses a patented transdermal delivery system to boost effectiveness. Early studies suggest it may reduce pain, inflammation, and red blood cell damage — key challenges in sickle cell disease. A Phase 1 trial is now underway, testing VAS-101 in two forms (topical and sublingual) to assess safety and its impact on blood flow, sickling, and oxygen release. If successful, this could open doors to a much-needed new therapy for a condition where pain management remains a major unmet need.

At OxyDial, we see this as a hopeful step toward better options for sickle cell patients, who deserve more than the limited treatments available today. While still early, VAS-101’s unique approach — especially its potential to tackle both pain and disease mechanisms — makes it one to watch.

📖 Read more: https://www.hcplive.com/view/vas-101-vasceptor-receives-orphan-drug-designation-for-sickle-cell-disease

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