A recent clinical trial published in Blood highlights a breakthrough in treating paroxysmal nocturnal hemoglobinuria (PNH). This rare, life-threatening blood disorder leads to the destruction of red blood cells. The study found that adding danicopan, a drug manufactured by Astra Zeneca, that targets extravascular hemolysis (EVH), to standard C5 inhibitors significantly improved hemoglobin levels, reduced the need for blood transfusions, and enhanced patients’ quality of life. Patients in the trial reported increased energy levels and reduced fatigue. Also, the study reinforces the need for personalized treatment strategies in managing PNH.

At Oxydial, we recognize this as a significant advancement in hematology and rare disease management. Innovation in targeted therapies continues to reshape patient care, and we remain committed to supporting precision medicine that improves outcomes for those with rare blood disorders.

Read more: https://medicalxpress.com/news/2025-02-clinical-trial-drug-combination-anemia.html#google_vignette

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